The rural centers integrations in the city which in some countries have been named as “urban villages” are the consequence of rapid urbanization and accelerated growth of our city. Since the rural centers integration in the city has been often without any plan, it has had various consequences on the environmental, physical, economical and social aspects. The present study has paid attention to the analysis of spatial-physical consequences of the rural centers integration in region one of Tehran within system approach toward the interaction of the both urban and rural settlements systems. In conducting the present research the statistical and spatial analyses have been utilized. In this regard, the data that were collected were related to the indicators used both in the rural residential and urban modernized areas. The conducted statistical-spatial analysis includes; T-test, multiple regression, overlapping layers and coefficient regression model in the geographic database. According to the results of the research, the physical-spatial consequences of rural centers integration in region one of Tehran have been manifested in two levels; the effects of rural centers and field and horticultural crops morphology of rural areason the invasive urban fabric and the interaction of the rural centers physical fabric and its exhaustive urban fabric. In addition to the effects on the identification of invasive urban fabric, the rural centers because of the unscheduled and any plan urban growth and organic shaping of the urban fabric under the influence of division and spatial structure of the field and horticultural crops morphology, has become erratic and sometimes impermeable. Regarding the rate of population and the high building density in the area, the impermeability of urban fabric in the integration areas, in addition to creating traffic problems, can create many problems in relieving the mentioned fabrics of the city when confronts with probable crisis. Also, the interaction of urban fabrics and rural centers has caused the shaping of unequal centers and physical-spatial inequality and disparity in the area. According to the results of the multi-variable regression analysis among physical-spatial indicators of the rural centers and their exhaustive urban fabric, the villages such as Valanjak, Gheitarieh and Asadabad have had the most inequality and disparity in their exhaustive urban fabric.